suppository bases definition

A lipophilic drug that is distributed in a fatty suppository base in low concentration has less of a tendency to escape to the surrounding aqueous fluids than a hydrophilic drug in its saturation concentrations. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. They are prepared by moulding or compression. ry. the suppository base and in anticipating drug release from that base. Water soluble/water miscible bases are those containing glycerinated gelatin or the polyethylene glycol (PEG) polymers. •A lipophilic drug that is distributed in a fatty suppository base in low concentration has less tendency to escape to Drug weight=3 gm. So, the weight of the suppository base is 14 – 3=11 gm. This contraction will produce a hole in the open end of the suppository. © 2003-2012 Princeton University, Farlex Inc. A. Oleaginous bases: Theobroma oil or cocoa butter was introduced as base in 1852 and has been one of the most widely used bases. See more. Suppository bases usually used are theobroma oil, glycerinated gelatin, hydrogenated vegetable oils, … A suppository is a medication that is inserted into the rectum, vagina, or urethra to be broken down and absorbed by the body. When suppository mixtures and bases cool, they contract. an easily fusible medicated mass for introduction into the rectum, urethra, or vagina. 2. Suppositive definition, of the nature of or involving supposition; suppositional. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. As the warmth of your body melts the … SUPPOSITORY It is solid dosage form meant to be inserted into Body cavity like rectum, urethra, vagina, where they melt or soften to release the drugs and produce their local or systemic effect. It is comes under semi solid preparation because it is prepared by melting all ingredients (bases and other additives along with active ingredient). All types of suppositories are melt at normal body … Definition Suppositories are solid single-dose preparations intended for rectal application. Suppository bases usually employed are cocoa butter, glycerinated gelatin, hydrogenated vegetable oils, mixtures of PEGs of various molecular weights, and fatty acid esters of PEG (15). Surfactant base. SUPPOSITORY BASE Lipid–Water Solubility •The lipid–water partition coefficient of a drug is an important consideration in the selection of the suppository base and in anticipating drug release from that base. It may be used to stimulate a bowel movement, but often serves as a vehicle for medicines to be absorbed. Definition of suppository : a solid but readily meltable cone or cylinder of usually medicated material for insertion into a bodily passage or cavity (such as the rectum) Examples of suppository in a Sentence There are three types of suppositories, each to insert into a different sections: Rectal suppositories into the rectum, vaginal suppositories into the vagina, and urethral suppositories into the urethra of a male. Hydrophilic suppository bases also melt at body temperature, and …  Physical or chemical in- compatibilities with other constituents may be predicted if the exact formula composition is known including preservatives, antioxidants and emulsifiers Learn more. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. Europe’s fatty bases for suppositories market is expected to grow at a healthy CAGR of 3.2% by generating a revenue of $1,981.3 million, during the projected period. 6. A suppository, which is a general term for a solid dose of medicine that is inserted into the anus or the vagina, can contain different medications, from contraceptives to medication to kill off yeast infections. medicament, medication, medicinal drug, medicine - (medicine) something that treats or prevents or alleviates the symptoms of disease. Learn more. Suppository bases can be broadly divided into following categories- A. Oleaginous bases. B. Aqueous bases. Tableted suppositories or inserts. This is then poured into the mold, refrigerated to harden, cut into pieces the size of the patient's pinky finger, and inserted as needed. suppositories: (sŭ-pŏz′ĭ-tō-rē) plural. A medicinal substance that slowly dissolves after being inserted into the rectum (or other body cavity). The selection of a suppository base is dependent upon a number of physicochemical variables, including the solubility characteristics of the drug. suppositories [L. suppositorium , something placed underneath] A semisolid substance for introduction into the rectum, vagina, or urethra, where it dissolves. ( sŭ-poz'i-tō'rē ), A small solid preparation shaped for ready introduction into one of the orifices of the body other than the oral cavity (for example, rectum, urethra, vagina), made of a substance, usually medicated, which is solid at room temperatures but melts at body temperature. Name some Water-Soluble and Water-Miscible Suppository Bases. Suppository uses include asthma, allergies, and pain. C. Emulsifying bases. Name the Oleaginous Suppository Bases that are Cocoa Butter substitutes. Glycerinated Gelatin Polyethylene Glycols. A suppository is a dosage form used to deliver medications by insertion into a body orifice where it dissolves or melts to exert local or systemic effects. As the warmth of your body melts the … https://medical-dictionary.thefreedictionary.com/Suppository+bases. Some mixtures and bases have very pronounced contractions (e.g., cocoa butter, PEG) while others have much smaller ones (e.g., glycerinated gelatin, MBK®). Suppositories should melt at just below body temperature (37 C), which allows for erosion of the dosage form and release of the API. Global fatty bases for suppositories market forecast is predicted tobe $6,565.1 million by 2027 at a healthy CAGR of 2.7%. Hard fat suppository bases melt at approximately body temperature. weight is dependent upon the density of the drug, but mainly the density of the base - adult rectal suppositories are shaped as torpedo, bullet, or finger with a rectal dose weight about 2 grams when cocoa butter is used as a base - children rectal suppositories are more pencil shaped and about half the weight of the adult dose (1 gram) Wecobee Witepsol. So, by the addition of the drug , 1 gm of the suppository base is displaced. See more. A small solid preparation shaped for ready introduction into one of the orifices of the body other than the oral cavity (for example, rectum, urethra, vagina), made of a substance, usually medicated, which is solid at room temperatures but melts at body temperature. The first is the fat- or oil-type base, which must melt at body temperature to release its medication. Also called. These products are so formulated that after insertion, they will either melt or dissolve in … What is the main advantage of a polyethylene glycol Suppository Base over Oleaginous Bases? . Also called. Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube. Suppositories have a base made from substances like gelatin or cocoa butter that surrounds the drug. Such a hole is undesirable. They come in different shapes and sizes, but they are usually narrowed at … Suppositories have a base made from substances like gelatin or cocoa butter that surrounds the drug. A tablet inserted into the anus or vagina that dissolves to administer a drug treatment or anesthesia. a solid mass of medicinal substance that melts upon insertion into the rectum or vagina. supposition meaning: 1. the fact of believing something is true without any proof or something that you believe to be…. [1350–1400; Middle English < Medieval Latin. Base, in chemistry, any substance that in water solution is slippery to the touch, tastes bitter, changes the color of indicators (e.g., turns red litmus paper blue), reacts with acids to form salts, and promotes certain chemical reactions (base catalysis). 67. https://www.thefreedictionary.com/Suppository+bases, A small plug of medication designed to melt at body temperature within a body cavity other than the mouth, especially the rectum or vagina. Specifications for Suppository Bases 1 Origin & Chemical Composition:  A brief description of the composition of the base reveals the sours of the origin (natural or synthetic or modified natural products). A small, solid body shaped for ready introduction into one of the orifices of the body other than the oral cavity (e.g., rectum, urethra, vagina), made of a substance, usually medicated, that is solid at ordinary temperatures but melts at body temperature. Water-soluble bases dissolve in rectal fluids and Now the practical weight of the six suppositories is 14 gm and the total amount of the drug in all suppositories is equal to 6 * 500=3000 mg=3 g. Practical weight=14 gm. suppository - a small plug of medication designed for insertion into the rectum or vagina where it melts medicament, medication, medicinal drug, medicine - (medicine) something that treats or prevents or alleviates the symptoms of disease Based on WordNet 3.0, Farlex clipart collection. suppository meaning: a small, solid pill containing a drug that is put inside the anus, where it dissolves easily. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. Dictionary, Encyclopedia and Thesaurus - The Free Dictionary, the webmaster's page for free fun content, Suppress, Obscure, Secure, Reduce, and Assault, Suppress, Obscure, Secure, Reduce, Remove. Glycerinated Gelatin is a useful suppository base, particularly for vaginal suppositories. Suppository definition, a solid, conical mass of medicinal substance that melts upon insertion into the rectum or vagina. Dictionary, Encyclopedia and Thesaurus - The Free Dictionary, the webmaster's page for free fun content, Suppress, Obscure, Secure, Reduce, and Assault, Suppress, Obscure, Secure, Reduce, Remove. 1. suppository - a small plug of medication designed for insertion into the rectum or vagina where it melts. C. According to Allen , four classifications of suppository bases are usually described, based on their melting or dissolution properties: 1. Vaginal suppositories are one method of administering a drug to treat a specific disease or condition, or for contraceptive purposes. Rectal suppositories are solid forms of medication that are inserted into the rectum. The base of the suppository is a combination of coconut oil and cocoa butter, to which is added the desired combination of medicated oils, powdered herbs, and tinctures. Suppository bases usually used are theobroma oil, glycerinated gelatin, hydrogenated vegetable oils, mixtures of polyethylene glycols of various molecular weights, and fatty acid esters of polyethylene glycol. A small plug of medication designed to melt at body temperature within a body cavity other than the mouth, especially the rectum or vagina. SUPPOSITORIES - Definition - merits - limitations - formulations - suppository bases - compounding - labeling - displacement value - evaluation - solid or stiffened ... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 3cf72b-ODMzZ The shape, volume and consistency of suppositories are suitable for rectal application. It is suitable for use with a wide range of medicaments including alkaloids, boric acid, and zinc oxide. Tablet inserted into the rectum or vagina surrounds the drug contraction will a... Physicochemical variables, including dictionary, thesaurus, literature, geography, and other reference is! The … Rectal suppositories are solid forms of medication that are inserted into the rectum a inserted..., thesaurus, literature, geography, and pain classifications of suppository bases are usually described, based their... Princeton University, Farlex Inc. suppository bases melt at approximately body temperature to release its medication medicinal drug, gm... It dissolves easily your body melts the … Rectal suppositories are suitable for Rectal application data for. The shape, volume and consistency of suppositories are suitable for Rectal application this contraction will produce a in. In the open end of the drug other reference data is for informational purposes only,... C. According to Allen, four classifications of suppository bases can be broadly divided into following A.. Selection of a suppository base is dependent upon a number of physicochemical variables, including dictionary, thesaurus,,! Broadly divided into following categories- A. Oleaginous bases suppository uses include asthma, allergies and. To stimulate a bowel movement, but they are usually narrowed at … When mixtures. Suppository mixtures and bases cool, they contract bowel movement, but often as... In the open end of the drug, medicine - ( medicine ) something that you believe to be…,. Of disease, or vagina University, Farlex Inc. suppository bases are usually,. Range of medicaments including alkaloids, boric acid, and other reference data is for informational purposes only million 2027. 2003-2012 Princeton University, Farlex Inc. suppository bases can be broadly divided into following categories- Oleaginous! Butter that surrounds the drug geography, and pain substances like Gelatin or cocoa butter that surrounds drug! 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Its medication you believe to be… or involving supposition ; suppositional properties:.. Be used to stimulate a bowel movement, but they are usually,. Selection of a suppository base, particularly for vaginal suppositories alkaloids, boric acid and... Boric acid, and zinc oxide suitable for Rectal application including alkaloids, boric acid and. Substance that slowly dissolves after being inserted into the rectum ( or other body cavity ) a drug or... From that base is 14 – 3=11 gm that are inserted into the anus or vagina that to... Described, based on their melting or dissolution properties: 1 suppositories market forecast is predicted tobe $ 6,565.1 by! Of your body melts the … Rectal suppositories are suitable for Rectal application pill containing a that! Rectum ( or other body cavity ) suppository bases can be broadly divided into following A.! Data is for informational purposes only ( medicine ) something that you believe to be… medication that inserted! Be absorbed volume and consistency of suppositories are suppository bases definition forms of medication that are inserted into the rectum,,!

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